Authors: N.G. Maljuta, N.N. Churilova, A.V. Sukhoverskaja, J.V. Zakharova

Title of the article: Oxidative coupling of oxime α-nitroacetophenone with aceto-acetic ether and toluene under the action ofoxidants

Year: 2018, Issue: 3, Pages: 101-111

Branch of knowledge: Chemical technology

Index UDK: 547.022

DOI: 10.26730/1999-4125-2018-3-101-111

Abstract: The urgency of the discussed issue: Among the reactions of the oxidative cross-coupling, C-O coupling is investigated to a lesser extent. Hence, the development of the methods of oxidative cross-coupling is one of the promising areas in modern organic chemistry. The process of oxidative C-O coupling develops in one stage. The main aim of the study: 1. To study the oxidative C-O coupling of β-dicarbonyl compounds (on the ex-ample of acetoacetic ether) with oxime of α-nitroacetophenone and α-nitroacetophenoneoxime with alkylarenes (for example, toluene) under the influence of oxidants. 2. To study the spectrum of antibacterial activity of substances of oxidative C-O coupling. The methods used in the study: IR spectroscopy, thermal analysis and the spectrum of antibacterial activity of the products obtained. The results: Studied the oxidative C-O coupling of β-dicarbonyl compounds (for example, acetoacetic ether) with oxime of α-nitroacetophenone under the action of oxidizing agents: KMnO4, Mn (OAc)2/ KMnO4, Co (OAc)2/ KMnO4 in acetic acid, as well as a poorly studied oxidative CO coupling of oxime of α-nitroacetophenone with alkylarenes (for example, toluene) in the presence of the same oxidants. The spectrum of antibacterial activity of the obtained products of oxidative C-O coupling was studied.

Key words: oximes oxidative cross-coupling IR spectra thermal analysis antibacterial activity

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